Scientific Interests:

Systems biology and functional genomics; studying phenotypes of organisms which arise from interactions between cellular components (biological networks)

Comparative molecular (systems) biology; understanding differences and similarities between species living in different environments at the genomic, proteomic and metabolic level

Protein structural bioinformatics; prediction and analysis of protein structures

Education and positions:

2009 - Post-doctoral research at the Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen, The Netherlands.

2009 - Doctoral degree (Ph.D) in bioinformatics and systems biology at the Center for Molecular and Biomolecular Informatics, Radboud University Nijmegen, The Netherlands.

2005 - Master of Science in Bioinformatics at the Radboud University Nijmegen, The Netherlands

Grants:

2009 - NWO (The Netherlands Organisation for Scientific Research) - Horizon Breakthrough

2009 - NWO (The Netherlands Organisation for Scientific Research) - VENI

Publications:

Notebaart R.A.*, Kensche P.R.*, Huynen M.A., Dutilh B.E. (2009), Asymmetric relationships between proteins shape genome evolution, Genome Biol., 10:R19 Pubmed, PDF, *contributed equally

Papp B., Teusink B., Notebaart R.A. (2009), A critical view of metabolic network adaptations, HFSP J, 3(1), 24-35 Pubmed, PDF

Teusink B., Wiersma A., Jacobs L., Notebaart R.A., Smid E.J. (2009), Understanding the adaptive growth strategy of L. plantarum on glycerol by in silico optimisation, PLoS Comput Biol, Pubmed, PDF

Verouden M.P.H.,Notebaart R.A., Westerhuis J.A., van der Werf M.J., Teusink B., Smilde A.K. (2009), Multi-way analysis of flux distributions across multiple conditions, J. Chemometrics, PDF 

Notebaart R.A., Teusink B., Siezen R.J., Papp B. (2008), Co-regulation of metabolic genes is better explained by flux coupling than by network distance, PLoS Comput Biol, 4, e26, Pubmed, PDF

Wessels E., Notebaart R.A., Duijsings D., Lanke K., Vergeer B., Melchers W.J., van Kuppeveld F.J. (2006), Structure-function analysis of the coxsackievirus protein 3A: Identification of residues important for dimerization, viral RNA replication, and transport inhibition, J. Biol. Chem. 281, 28232-28243. Pubmed, PDF

Notebaart R.A., van Enckevort F.J.H., Francke C., Siezen R.J., Teusink B. (2006), Accelerating the reconstruction of genome-scale metabolic networks, BMC Bioinformatics, 7, 296. Pubmed, PDF

Notebaart R.A., Huynen M.A., Teusink B., Siezen R.J., Snel B. (2005), Correlation between sequence conservation and the genomic context after gene duplication, Nucleic Acids Res. 33, 6164-6171. Pubmed, PDF

Wessels E., Duijsings D., Notebaart R.A., Melchers W.J.G., van Kuppeveld F.J.M. (2005), A Proline-Rich Region in the Coxsackievirus 3A Protein Is Required for the Protein To Inhibit Endoplasmic Reticulum-to-Golgi Transport, J. Virol. 79, 5163-5173. Pubmed, PDF

Collaborators:

Balázs Papp: Biological Research Centre (BRC), Szeged, Hungary and Cambridge University, UK

Csaba Pál: Biological Research Centre (BRC), Szeged, Hungary

Seminar:

Systems biology / Modeling large biological networks, click here